IMMUNOMODULATETING POTENTIAL OF
HOMOEOPATHIC MEDICINE BAPTISIA 30IN HUMAN AND ANIMAL MODELS |
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| Dr. S.M. Singh |
| M.D. (Homoeopathy) |
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| Homoeopathic drugs are used to treat successfully many infectious diseases caused by microorganism of all groups such as bacteria, virus, fungus etc. not only in human beings in plant and animal kingdom. It is also now that cause of infection in particular individual depends upon the immunological status of the host.
In this series the use and effectiveness of Baptisia 30 Potency in the treatment of Enteric fever (Typhoid) has been established beyond any doubt. Therefore, it was thought pertinent to examine the effect of Baptisia on immune system of the body.
Drugs modulating the immunological reactivity of the host may act either by suppressing or by enhancing one or more than one of the following components of the immune system as suggested by Meyers, etal. (1976). |
(1) Antigen recognition and phagocytosis.
(2) Proliferation of lymphocytes
(3) Synthesis of antibody.
(4) Antigen-antibody interaction.
(5) Complement system.
(6) target tissue which is involved in immunological reactions
(7) Mediators released due to the antigen-antibody reactions and their receptor sites
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In the present study, however, the effect of Baptisia has been assessed on synthesis of antibody because available literature speaks more about this aspect; hence, a systematic study is required to verify the claims.
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| Material and Method: |
In the present study, effect of Baptisia 30 was screened on antibody production.
Both animal as well as human models were employed. |
| Animal Model: |
| Albino rabbits were selected for animal studies because rabbits are reported to be resistant to natural typhoid infection. 35 rabits of either sex used in this study were between 1.5-2 Kg. weight kept in identical living conditions (normal diet and water adlibitum allowed). Eighteen (18) rabbits were divided in to three groups and were treated as under. |
| Group One: Non Vaccinated and non-drug treated
Group Two: In this group formaline killed suspension of salmonella typhi (Typhoid H antigen) having 458 million bacteria /ml was injected S/C in a single dose of 1 ml.
Group Three: Inoculation with typhoid antigen as in second group but these
Blood was collected on 10 th day and antibody titre was determined by the Method of widal Agglutination test (Cruckshank. 1955). |
Human Model: |
| Study on human model was conducted by selecting 12 persons of either sex of same living conditions between 22-35 years of age . The effect of Baptisia (30) was assessed by dividing them into two group. |
| First Group: served as control, no drug was administered.
Second Group: This group was given Baptisia (30) 5-pellets, three times a day For a period of 10 days
Blood was collected on 10th day and serum immunoglobulin estimation was done by the help of solugen plan stried plates obtained from Immuno Diagnostics Pvt.Ltd. the method immunoglobulin estimation was described by Mancini. |
| Observations and result: |
| The results obtained in the present study are summarized in table I and II.
Analysis of Table I and II of the present study reveals that Baptisia (30) in rabbit significantly, diminished the antibody titre induced by S. Typhi H antigen. Similarly, in response to Baptisia 30 administration . The rise in immunoglobulin observed was preferential in nature eg.: |
Ig M < Ig A < Ig G |
Table I. effect of Baptisia 30 on experimentally induced immune response in rabbit.
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| Groups |
Treatment given |
ANTIBODY TITRE |
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RANGE |
MEAN +SE |
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| I |
Nonvaccinated and Non drug treated |
Nigative |
-- |
| II |
Vaccinated with S. typhi H Antigen only |
320-960 |
460 +15.6 |
| III |
Vaccinated with S. typhi H Antigen Baptisia (30) for 10 Days |
20-80 |
50 + 12.6 |
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Table II Table I. effect of Baptisia 30 on serum immunoglobulin levels In healthy human volunteers.
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| Groups |
SERUM IMMUNOGLOBULIN LEVELS |
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Ig M |
Ig G |
Ig A |
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| Control and Non drug |
130.67+47 |
1386.67 + 192.58 |
226.5+ 98.03 |
| Drug treated with Baptisia 30 th -three Times a day fir 10 days |
146+ 18.57 |
1427 +157.44 |
162 +106.45 |
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| DISCUSSION: |
In the present study the observation reveals two distinct striking observations:
 In animal model, Baptisia 30th counteracted the immune response evoked by S. Typhi antigen an organism responsible far typhoid fever.
In human dodel, however in healthy volunteers the Baptisia 30th increased the level of immunoglobulin more preferentially of Ig G type
Therefore, our findings are exactly in conformity to what has been described in homoeopathic literature
Cowperthwaite, described that Baptisia acts especially upon the bood having a disorganizing and discomposing influence producing a state similar to that present in low froms of fever and typhoid fever. In typhoid fever, Baptisia is also useful in the first week during the stage of hyperemia before ulceration of player’s glands has teken place. If properly indicated and given at this stage it will, undoubtly,abort the disease.
William Boericke M.D., emphasized that Baptisia is low dilution produces a from of antibodies to the bacteria typhoids viz. agglutinins.thus, it raise s the normal body resistance to the invasion of bacteria of bacillary intoxication which produces the typhoid syndrome and typhoid carrier and after inculation with antityphoid serum
Nesh,another homoeopathic authority said, “I have aborted many cases of typhoid in the first stage, I have used both the low and high preparation with equal success.
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